Diabetic Nephropathy

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Stages of Diabetic Nephropathy (IDDM)

Stage I : 0 years

Raised GFR, Increased Renal Size & Plasma flow due to increased afferent arteriole diameter

Normal Afferent Arteriole
Normal Afferent Arteriole

 

Dialated Afferent Arteriole
Dilated Afferent Arteriole

 

Stage II : 2 years

Thickened glomerular basement membrane

 

Normal Glomerular Basement Membrane
Normal Glomerular Basement Membrane

 

Thickened GBM
Thickened GBM

 

Stage III : 6-10 years

Microabluminurea

Albumin Leakage through GBM
Albumin Leakage through GBM

Stage IV : 10-15 years

Overt Proteinurea & Clinical Nephropathy

Changes are IRREVERSIBLE

Stage V : 16-25 years

End Stage Renal Disease

 

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