Endometrial Carcinoma

Risk Factor

Relieving Factors




Histological Differentiation

Type 1 is Estrogen dependent, so mostly found in PRE-Menopausal & PERI-Menopausal 

Type 2 is Estrogen independent, so mostly found in POST-Menopausal

Clear Cell form is most Aggresive & Hub Nail Appearance

Clinical features

OLD Staging


There are 4 Stages

Stage I [A, B, C]

Confined to Uterus

1A– Confined to Endometrium ONLY

1B–  <50% Myometrium Invasion

1C–  ≥ 50% Myometrium Invasion


Stage II [A, B]

Confined to Cervix

II A– Involvement of Cervical GLAND ONLY

II BStroma Involvement


Stage III [A, B, C]

III A – Peritoneal Involvement

III B – Vagianal Involvement

III C – Para-Aortic Lymphnode


Stage IV [A, B]

IV A- Regional Metastasis to Bowel & Bladder

IV B- Distant Metastasis to Abdomen


Revised Staging in 2009

Revised Staging I A = Old I A + I B

Revised Staging I B = Old I C

Revised Satging II = Old II B

Revised Staging III A & B UNCHANGED, but III C is devided to C1 [Pelvic Lymphnode] & C2[Para-Aortic Lymphnode]

Revised Staging for IV is UNCHANGED.



Screening – PAP Smear

First Investigation – Transvaginal Sonography

Investigation of Choice – Endometrial Aspiration & Biopsy

Gold Standard – Fractional Curettage



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5 thoughts on “Endometrial Carcinoma

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